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Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.
Pal M, Muñoz-Hernandez H, Bjorklund D, Zhou L, Degliesposti G, Skehel JM, Hesketh EL, Thompson RF, Pearl LH, Llorca O, Prodromou C. Pal M, et al. Cell Rep. 2021 Jul 6;36(1):109317. doi: 10.1016/j.celrep.2021.109317. Cell Rep. 2021. PMID: 34233195 Free PMC article.
The R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) complex, in collaboration with heat shock protein 90 (HSP90), functions as a chaperone for the assembly and stability of protein complexes, including RNA polymerases, small nuclear ribonucleoprotein particles (snRNPs), and phosphatidylinosito …
The R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) complex, in collaboration with heat shock protein 90 (HSP90), functions as a chaperone for the assembl …
Structure of the Human TELO2-TTI1-TTI2 Complex.
Kim Y, Park J, Joo SY, Kim BG, Jo A, Lee H, Cho Y. Kim Y, et al. J Mol Biol. 2022 Jan 30;434(2):167370. doi: 10.1016/j.jmb.2021.167370. Epub 2021 Nov 24. J Mol Biol. 2022. PMID: 34838521
TTI1 provides a platform on which TELO2 and TTI2 bind to its central region and C-terminal end, respectively. ...The TELO2 CTD and TTI1 N- and C-terminal segments are required for cell survival in response to ionizing radiation....
TTI1 provides a platform on which TELO2 and TTI2 bind to its central region and C-terminal end, respectively. ...The TELO2 …
Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly.
Serey-Gaut M, Cortes M, Makrythanasis P, Suri M, Taylor AMR, Sullivan JA, Asleh AN, Mitra J, Dar MA, McNamara A, Shashi V, Dugan S, Song X, Rosenfeld JA, Cabrol C, Iwaszkiewicz J, Zoete V, Pehlivan D, Akdemir ZC, Roeder ER, Littlejohn RO, Dibra HK, Byrd PJ, Stewart GS, Geckinli BB, Posey J, Westman R, Jungbluth C, Eason J, Sachdev R, Evans CA, Lemire G, VanNoy GE, O'Donnell-Luria A, Mau-Them FT, Juven A, Piard J, Nixon CY, Zhu Y, Ha T, Buckley MF, Thauvin C, Essien Umanah GK, Van Maldergem L, Lupski JR, Roscioli T, Dawson VL, Dawson TM, Antonarakis SE. Serey-Gaut M, et al. Am J Hum Genet. 2023 Mar 2;110(3):499-515. doi: 10.1016/j.ajhg.2023.01.006. Epub 2023 Jan 31. Am J Hum Genet. 2023. PMID: 36724785 Free PMC article.
Telomere maintenance 2 (TELO2), Tel2 interacting protein 2 (TTI2), and Tel2 interacting protein 1 (TTI1) are the three components of the conserved Triple T (TTT) complex that modulates activity of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), includ …
Telomere maintenance 2 (TELO2), Tel2 interacting protein 2 (TTI2), and Tel2 interacting protein 1 (TTI1) are the three compone …
TTI1 promotes non-small-cell lung cancer progression by regulating the mTOR signaling pathway.
Zhang LX, Yang X, Wu ZB, Liao ZM, Wang DG, Chen SW, Lu F, Wu YB, Zhu SQ. Zhang LX, et al. Cancer Sci. 2023 Mar;114(3):855-869. doi: 10.1111/cas.15668. Epub 2022 Dec 7. Cancer Sci. 2023. PMID: 36403197 Free PMC article.
The role of TELO2-interacting protein 1 (TTI1) in the progression of several types of cancer has been reported recently. ...Notably, patients with overexpression of TTI1 or Ki67 had a shorter overall survival rate and a higher disease-free survival rate compa …
The role of TELO2-interacting protein 1 (TTI1) in the progression of several types of cancer has been reported recently. ...No …
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Fernández-Sáiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, Kurutz J, Peschel C, Pagano M, Kuster B, Bassermann F. Fernández-Sáiz V, et al. Nat Cell Biol. 2013 Jan;15(1):72-81. doi: 10.1038/ncb2651. Nat Cell Biol. 2013. PMID: 23263282
The Tel2 (also known as Telo2) and Tti1 proteins control the cellular abundance of mammalian PIKKs and are integral components of mTORC1 and mTORC2. Here we report that Tel2 and Tti1 are targeted for degradation within mTORC1 by the SCFFbxo9 ubiquitin ligase …
The Tel2 (also known as Telo2) and Tti1 proteins control the cellular abundance of mammalian PIKKs and are integral components …
Exploring the Functional Roles of Telomere Maintenance 2 in the Tumorigenesis of Glioblastoma Multiforme and Drug Responsiveness to Temozolomide.
Feng SW, Wu ZS, Chiu YL, Huang SM. Feng SW, et al. Int J Mol Sci. 2023 May 25;24(11):9256. doi: 10.3390/ijms24119256. Int J Mol Sci. 2023. PMID: 37298208 Free PMC article.
Hence, it is urgent to address the functional role of TELO2 in the tumorigenesis and TMZ treatment of GBM. In this study, we knocked down TELO2 mRNA in GBM8401 cells, a grade IV GBM, compared with TELO2 mRNA overexpression in human embryonic glial SVG p12 cel …
Hence, it is urgent to address the functional role of TELO2 in the tumorigenesis and TMZ treatment of GBM. In this study, we knocked …
Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients.
Buttarelli M, Ciucci A, Palluzzi F, Raspaglio G, Marchetti C, Perrone E, Minucci A, Giacò L, Fagotti A, Scambia G, Gallo D. Buttarelli M, et al. J Exp Clin Cancer Res. 2022 Feb 4;41(1):50. doi: 10.1186/s13046-022-02265-w. J Exp Clin Cancer Res. 2022. PMID: 35120576 Free PMC article.
The ten-gene signature included: CKB (Creatine kinase B), CTNNBL1 (Catenin, beta like 1), GNG11 (G protein subunit gamma 11), IGFBP7 (Insulin-like growth factor-binding protein 7), PLCG2 (Phospholipase C, gamma 2), RNF24 (Ring finger protein 24), SLC15A3 (Solute carrier family 15 …
The ten-gene signature included: CKB (Creatine kinase B), CTNNBL1 (Catenin, beta like 1), GNG11 (G protein subunit gamma 11), IGFBP7 (Insuli …
Novel Compound Heterozygous Mutations in TTI2 Cause Syndromic Intellectual Disability in a Chinese Family.
Wang R, Han S, Liu H, Khan A, Xiaerbati H, Yu X, Huang J, Zhang X. Wang R, et al. Front Genet. 2019 Oct 29;10:1060. doi: 10.3389/fgene.2019.01060. eCollection 2019. Front Genet. 2019. PMID: 31737043 Free PMC article.
Telomere maintenance 2 (TELO2)-interacting protein 2 (TTI2) interacts with TTI1 and TELO2 to form the Triple T complex, which is required for various cellular processes, including the double-strand DNA break response, nonsense-mediated mRNA decay, and telomer …
Telomere maintenance 2 (TELO2)-interacting protein 2 (TTI2) interacts with TTI1 and TELO2 to form the Triple T complex, …
Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability.
Ziegler A, Bader P, McWalter K, Douglas G, Houdayer C, Bris C, Rouleau S, Coutant R, Colin E, Bonneau D. Ziegler A, et al. Clin Genet. 2019 Oct;96(4):354-358. doi: 10.1111/cge.13603. Epub 2019 Jul 17. Clin Genet. 2019. PMID: 31290144
Together with severe ID, progressive microcephaly, scoliosis and sleeping disorder are the most striking features in the two individuals concerned. TTI2, together with TTI1 and TELO2, encode proteins that constitute the triple T heterotrimeric complex. ...Pathogenic …
Together with severe ID, progressive microcephaly, scoliosis and sleeping disorder are the most striking features in the two individuals con …
Advances on the Structure of the R2TP/Prefoldin-like Complex.
Muñoz-Hernández H, Pal M, Rodríguez CF, Prodromou C, Pearl LH, Llorca O. Muñoz-Hernández H, et al. Adv Exp Med Biol. 2018;1106:73-83. doi: 10.1007/978-3-030-00737-9_5. Adv Exp Med Biol. 2018. PMID: 30484153
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